Note

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Different models of diffusion MRI can be compared based on their accuracy in fitting the diffusion signal. Here, we demonstrate this by comparing two models: the diffusion tensor model (DTI) and Constrained Spherical Deconvolution (CSD). These models differ from each other substantially. DTI approximates the diffusion pattern as a 3D Gaussian distribution, and has only 6 free parameters. CSD, on the other hand, fits many more parameters. The models aare also not nested, so they cannot be compared using the log-likelihood ratio.

A general way to perform model comparison is cross-validation [Hastie2008]. In
this method, a model is fit to some of the data (a *learning set*) and the
model is then used to predict a held-out set (a *testing set*). The model
predictions can then be compared to estimate prediction error on the held out
set. This method has been used for comparison of models such as DTI and CSD
[Rokem2014], and has the advantage that it the comparison is imprevious to
differences in the number of parameters in the model, and it can be used to
compare models that are not nested.

In DIPY_, we include an implementation of k-fold cross-validation. In this method, the data is divided into \(k\) different segments. In each iteration :math:` rac{1}{k}th` of the data is held out and the model is fit to the other :math:` rac{k-1}{k}` parts of the data. A prediction of the held out data is done and recorded. At the end of \(k\) iterations a prediction of all of the data will have been conducted, and this can be compared directly to all of the data.

First, we import that modules needed for this example. In particular, the
`reconst.cross_validation`

module implements k-fold cross-validation

```
import numpy as np
np.random.seed(2014)
import matplotlib.pyplot as plt
import dipy.data as dpd
import dipy.reconst.cross_validation as xval
import dipy.reconst.dti as dti
import dipy.reconst.csdeconv as csd
import scipy.stats as stats
from dipy.core.gradients import gradient_table
from dipy.io.image import load_nifti
from dipy.io.gradients import read_bvals_bvecs
```

We fetch some data and select a couple of voxels to perform comparisons on. One lies in the corpus callosum (cc), while the other is in the centrum semiovale (cso), a part of the brain known to contain multiple crossing white matter fiber populations.

```
hardi_fname, hardi_bval_fname, hardi_bvec_fname = dpd.get_fnames('stanford_hardi')
data, affine = load_nifti(hardi_fname)
bvals, bvecs = read_bvals_bvecs(hardi_bval_fname, hardi_bvec_fname)
gtab = gradient_table(bvals, bvecs)
cc_vox = data[40, 70, 38]
cso_vox = data[30, 76, 38]
```

We initialize each kind of model:

```
dti_model = dti.TensorModel(gtab)
response, ratio = csd.auto_response_ssst(gtab, data, roi_radii=10, fa_thr=0.7)
csd_model = csd.ConstrainedSphericalDeconvModel(gtab, response)
```

Next, we perform cross-validation for each kind of model, comparing model predictions to the diffusion MRI data in each one of these voxels.

Note that we use 2-fold cross-validation, which means that in each iteration, the model will be fit to half of the data, and used to predict the other half.

```
dti_cc = xval.kfold_xval(dti_model, cc_vox, 2)
csd_cc = xval.kfold_xval(csd_model, cc_vox, 2, response)
dti_cso = xval.kfold_xval(dti_model, cso_vox, 2)
csd_cso = xval.kfold_xval(csd_model, cso_vox, 2, response)
```

We plot a scatter plot of the data with the model predictions in each of these voxels, focusing only on the diffusion-weighted measurements (each point corresponds to a different gradient direction). The two models are compared in each sub-plot (blue=DTI, red=CSD).

```
fig, ax = plt.subplots(1, 2)
fig.set_size_inches([12, 6])
ax[0].plot(cc_vox[gtab.b0s_mask == 0], dti_cc[gtab.b0s_mask == 0], 'o',
color='b', label='DTI in CC')
ax[0].plot(cc_vox[gtab.b0s_mask == 0], csd_cc[gtab.b0s_mask == 0], 'o',
color='r', label='CSD in CC')
ax[1].plot(cso_vox[gtab.b0s_mask == 0], dti_cso[gtab.b0s_mask == 0], 'o',
color='b', label='DTI in CSO')
ax[1].plot(cso_vox[gtab.b0s_mask == 0], csd_cso[gtab.b0s_mask == 0], 'o',
color='r', label='CSD in CSO')
ax[0].legend(loc='upper left')
ax[1].legend(loc='upper left')
for this_ax in ax:
this_ax.set_xlabel('Data (relative to S0)')
this_ax.set_ylabel('Model prediction (relative to S0)')
fig.savefig("model_predictions.png")
```

We can also quantify the goodness of fit of the models by calculating an R-squared score:

```
cc_dti_r2 = stats.pearsonr(cc_vox[gtab.b0s_mask == 0],
dti_cc[gtab.b0s_mask == 0])[0]**2
cc_csd_r2 = stats.pearsonr(cc_vox[gtab.b0s_mask == 0],
csd_cc[gtab.b0s_mask == 0])[0]**2
cso_dti_r2 = stats.pearsonr(cso_vox[gtab.b0s_mask == 0],
dti_cso[gtab.b0s_mask == 0])[0]**2
cso_csd_r2 = stats.pearsonr(cso_vox[gtab.b0s_mask == 0],
csd_cso[gtab.b0s_mask == 0])[0]**2
print("Corpus callosum\n"
"DTI R2 : %s\n"
"CSD R2 : %s\n"
"\n"
"Centrum Semiovale\n"
"DTI R2 : %s\n"
"CSD R2 : %s\n" % (cc_dti_r2, cc_csd_r2, cso_dti_r2, cso_csd_r2))
```

Out:

```
Corpus callosum
DTI R2 : 0.7828795917129329
CSD R2 : 0.8051656184264897
Centrum Semiovale
DTI R2 : 0.43192536287612576
CSD R2 : 0.6038698891074307
```

This should look something like this:

Corpus callosum

DTI R2 : 0.782881752597

CSD R2 : 0.805764364116

Centrum Semiovale

DTI R2 : 0.431921832012

CSD R2 : 0.604806420501

As you can see, DTI is a pretty good model for describing the signal in the CC, while CSD is much better in describing the signal in regions of multiple crossing fibers.

- Hastie2008
Hastie, T., Tibshirani, R., Friedman, J. (2008). The Elements of Statistical Learning: Data Mining, Inference and Prediction. Springer-Verlag, Berlin

- Rokem2014
Rokem, A., Chan, K.L. Yeatman, J.D., Pestilli, F., Mezer, A., Wandell, B.A., 2014. Evaluating the accuracy of diffusion models at multiple b-values with cross-validation. ISMRM 2014.

**Total running time of the script:** ( 0 minutes 3.473 seconds)